Gentaur has developed prototype assays capable of measuring the oligomeric and aggregated forms (if present) of ß-amyloid, α-synuclein, and phospho-tau in blood. The assays have been tested on blood samples from patients with Alzheimer’s syndrome, Parkinson’s condition, and Dementia with Lewy Bodies. Some example data are shown below.
We are currently recruiting samples from individuals with Parkinson’s and non-Parkinson’s tremors to demonstrate that misdiagnosed patients can be accurately identified helping to avoid unnecessary treatment costs. This study is expected to be completed by the end of 2016.
We are also recruiting samples from healthy controls across a range of ages to investigate whether there is evidence of age-related accumulation of the aggregated forms of all three proteins.
Results on the measurement of ß-amyloid and α-synuclein in real blood samples from patients with Alzheimer’s syndrome, Parkinson’s condition, and Dementia with Lewy Bodies were compared to those from healthy controls under the age of 30 and two spouses.
